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Caduet y Enfermedad del higado

Resultado de la verificación de la interacción del medicamento Caduet y la enfermedad de Enfermedad del higado en la seguridad cuando se comparte.

Resultado de la verificación:

Caduet <> Enfermedad del higado

Relevancia: 23.07.2019 Examinador: P.M. Shkutko, M.D., in

Al verificar la interacción según fuentes acreditadas Drugs.com, Rxlist.com, Webmd.com, Medscape.com contraindicaciones o efectos secundarios se han encontrado que pueden causar daño o aumentar el efecto negativo cuando el medicamento se usa con esta enfermedad concomitante.

Consumidor:

Bloqueadores del canal de calcio (Ccb) se metaboliza extensamente por el hígado. La vida media de la Ccb puede ser prolongado sustancialmente en los pacientes con insuficiencia hepática grave, con el potencial significativo de acumulación del fármaco. Además, el uso de algunos Ccb ha sido asociado con elevaciones en las transaminasas séricas, con y sin la consiguiente elevación de la fosfatasa alcalina y de la bilirrubina. Aunque estos efectos pueden ser transitorios y reversibles, varios pacientes que han desarrollado la colestasis o lesión hepatocelular que fue probado por la reexposición. La terapia con Ccb debe ser administrado con cautela y, a menudo, en la reducción de las dosis en los pacientes con significativamente el deterioro de la función hepática. El control periódico de la función hepática y para el exceso de efectos farmacológicos (por ejemplo, prolongación anormal del intervalo PR) es advertido, y se debe ajustar la dosis si es necesario.

Fuentes

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Caduet

Nombre genérico: amlodipine / atorvastatin

Marca comerciale: Caduet

Sinónimos: no

¿Qué es Caduet?

Otro medicamento Eliminar

Caduet <> Enfermedad del higado

Relevancia: 23.07.2019 Examinador: P.M. Shkutko, M.D., in

Consumidor:

El uso de inhibidores de la HMG-CoA reductasa está contraindicado en pacientes con enfermedad hepática activa o inexplicable, elevaciones persistentes de las transaminasas séricas. Inhibidores de la HMG-CoA reductasa se metaboliza extensamente por el hígado. Disminución del metabolismo de los fármacos puede conducir a la acumulación y aumento del riesgo de toxicidad, incluyendo anormalidades bioquímicas de función hepática y, rara vez, ictericia, hepatitis, cirrosis, esteatosis cambio en el hígado, y necrosis hepática fulminante. La terapia con inhibidores de la HMG-CoA reductasa debe ser administrado con precaución en pacientes con antecedentes de enfermedad hepática y/o el uso excesivo de alcohol. Una menor dosis inicial puede ser apropiado, y la vigilancia clínica de los niveles de transaminasas hepáticas según el paquete del producto etiquetado se recomienda. Los pacientes que desarrollan elevación de ALT o AST niveles durante la terapia deben ser monitoreados hasta que las anomalías resolver. Si un aumento por encima de 3 veces el límite superior de lo normal persiste, debe considerarse una reducción de la dosis o la suspensión de la terapia.

Fuentes

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