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Lorazepam Oral Concentrate y Enfermedad renal / hepática

Resultado de la verificación de la interacción del medicamento Lorazepam Oral Concentrate y la enfermedad de Enfermedad renal / hepática en la seguridad cuando se comparte.

Resultado de la verificación:

Lorazepam Oral Concentrate <> Enfermedad renal / hepática

Relevancia: 23.07.2019 Examinador: P.M. Shkutko, M.D., in

Al verificar la interacción según fuentes acreditadas Drugs.com, Rxlist.com, Webmd.com, Medscape.com contraindicaciones o efectos secundarios se han encontrado que pueden causar daño o aumentar el efecto negativo cuando el medicamento se usa con esta enfermedad concomitante.

Consumidor:

Las benzodiazepinas son metabolizados por el hígado y los metabolitos se excretan en la orina. Chlordiazepoxide, clorazepato, diazepam, flurazepam y quazepam someterse a oxidativa de N-dealquilación a los metabolitos activos que sean sustancialmente de acción más prolongada que la del compuesto original. Estos metabolitos luego se someten a más de biotransformación a farmacológicamente inactivos de productos antes de su excreción por el riñón. La terapia con benzodiacepinas debe ser administrado con cautela a bajas dosis inicial en pacientes con insuficiencia renal y/o hepática. Los agentes que se convierten en poco activo, de acción corta, o metabolitos inactivos puede ser preferible en insuficiencia hepática. El Lorazepam, oxazepam y temazepam se conjugan a metabolitos inactivos, mientras que el alprazolam, estazolam y triazolam someterse a la hidroxilación a débilmente activos o metabolitos inactivos.

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